Tijaabooyin Caafimaad

Ujeedada: Ujeedada daraasaddan ayaa ah in la qiimeeyo farmasiga iyo farmasiga (PK-PD) profiles of lispro ay maamusho cirbad-la'aanta jetka QS-M ee maadooyinka Shiinaha.

Naqshadeynta cilmi baarista iyo hababka: A randomized, double-inard, double-dummy, daraasad isdhaafsi ah ayaa la sameeyay. Sideed iyo toban mutadawiciin caafimaad qaba ayaa la qoray. Lispro (0.2 halbeeg/kg) waxaa maamulayay cirbad-la'aanta jetka QS-M ama qalinka caadiga ah. Tijaabooyin isku-qabsi oo toddobo saacadood ah ayaa la sameeyay. Sideed iyo toban mutadawiciin ah (sagaal rag ah iyo sagaal dumar ah) ayaa lagu qoray daraasaddan. Shuruudaha ka mid noqoshada waxay ahaayeen: kuwa aan sigaarka cabbin ee da'doodu tahay 18-40 sano, oo leh index mass index (BMI) ee 17-24 kg / m2; maadooyinka leh shaybaarada caadiga ah ee biochemical, cadaadiska dhiigga, iyo electrocardiograph; maadooyinka saxeexay oggolaanshaha la wargeliyey. Shuruudaha ka-saarista waxay ahaayeen: maaddooyinka xasaasiyadda insulinta ama taariikhda xasaasiyadda kale; dadka qaba cudurrada daba-dheeraada sida sonkorowga, cudurrada wadnaha iyo xididdada dhiigga, cudurrada beerka ama kelyaha. Mawduucyadii isticmaalay khamriga sidoo kale waa laga saaray. Daraasadda waxaa ansixiyay Guddiga Anshaxa ee Cusbitaalka ugu horreeya ee ku xiran Jaamacadda Caafimaadka ee Chongqing.

Natiijooyinka: Meel weyn oo ka hooseeya qalooca (AUCs) ee feejignaanta insulinta iyo heerka faleebo gulukoos (GIR) inta lagu jiro daqiiqadaha 20 ee ugu horreeya ka dib duritaanka lispro ee cirbadeynta jetka marka la barbardhigo qalinka insulinta ayaa la arkay (24.91 ± 15.25 vs. 12.52 ± 7.60 mg. kg-1, P <0.0.00 ± min 0.24 vs. 0.10 ± 0.04 U min L-1, P <0.001 ee AUCINS, 0-20 min). Cirbad la'aanta irbad la'aanta waxay muujisay wakhti gaaban oo lagu gaaro qiyaasta insulinta ugu badan (37.78 ± 11.14 vs. 80.56 ± 37.18 min, P <0.001) iyo GIR (73.24 ± 29.89 vs. 116.18 ± 51.89 min, P = 0.06). Ma jirin farqi u dhexeeya wadarta soo-gaadhista insulinta iyo saamaynta hypoglycemic ee u dhaxaysa labada aaladood. Gabagabo: Lispro ay maamusho cirbad la'aanta QS-M waxay keenaysaa soo-gaadhis insulin hore iyo ka sarraysa marka loo eego qalinka caadiga ah, iyo saamayn hore oo gulukoos-hoosaysa oo leh awood guud oo la mid ah.